Publications
2026
Guida N., Ruggiero S., Serani A., Sisalli M.J., Mascolo L., Sanguigno L., Ferrante A., Cuomo O., D'Apolito E., Laudati G., Scorziello A., Pignataro G., Annunziato L., Formisano L.
DNA hydroxymethylation of NCX1 heart promoter by GATA6/TET3 epigenetic complex participates in neuroprotection induced by hypoxic preconditioning
Biomedicine and Pharmacotherapy, vol. 199
2026
Squarzoni A., Boschetti G., Bertozzi S.M., Summa M., Serani A., Milandri E., Mandrioli R., Protti M., Mercolini L., Montani C., Capodivento G., Cangemi G., Pedemonte N., Bandiera T., Benfenati F., Nobbio L., Bertorelli R., Armirotti A.
Exposure of dams to Elexacaftor/ Tezacaftor/Ivacaftor during pregnancy and breastfeeding induces reversible alterations in newborn wild type CD-1 mice
Journal of Cystic Fibrosis, vol. 25, (no. 1), pp. 13-20
2026
Morelli G., Visintin G., Gelli E., Serani A., Bartolucci M., Uccella S., D'Apruzzo M., Preiti D., Chellali M.M., Cucinelli A., Rastogi M., Falappa M., Scalabrini A., Turecki G., Petretto A., Tucci V., Cancedda L.
Traumatic life experiences during critical periods lead to diverse developmental trajectories
Cell Reports Medicine, vol. 7, (no. 6)
2025
Wolff R., Balzani E., Gelli E., Polito A., Serani A., Tucci V.
Monoallelic gene expression in developing cells increases genetic noise and Shannon entropy
Communications Biology, vol. 8, (no. 1)
2025
Sanguigno L., Guida N., Cammarota M., Ruggiero S., Serani A., Galasso F., Pizzorusso V., Boscia F., Formisano L.
Role of NRP1/HDAC4/CREB/RIPK1 Axis in SARS-CoV2 S1 Spike Subunit-Induced Neuronal Toxicity
FASEB BioAdvances, vol. 7, (no. 8)
2025
Ruggiero S., Guida N., Mascolo L., Serani A., Ferrante A., Galasso F., Sanguigno L., Piemonte E., De Rosa E., Montuori P., Triassi M., Di Renzo G., Galgani M., Formisano L.
Sp4/HD11 and Sp1/HAT-p300 complexes induce apoptotic cell death in CuCl2-treated neurons by modulating histone acetylation on BCL-W and BAX promoters
Neurochemistry International, vol. 186
2024
Guida N., Serani A., Sanguigno L., Mascolo L., Cuomo O., Fioriniello S., Marano D., Della Ragione F., Anzilotti S., Brancaccio P., Molinaro P., Pignataro G., Annunziato L., Formisano L.
Stroke Causes DNA Methylation at Ncx1 Heart Promoter in the Brain Via DNMT1/ MeCP2/REST Epigenetic Complex
Journal of the American Heart Association, vol. 13, (no. 6)
2023
Melloni A., Serani A., Tucci V.
Parental genome and brain functions: The case of genomic imprinting
Principles of Gender-Specific Medicine: Sex and Gender-Specific Biology in the Postgenomic Era, pp. 301-312, Publisher: Elsevier
2023
Sanguigno L., Guida N., Anzilotti S., Cuomo O., Mascolo L., Serani A., Brancaccio P., Pennacchio G., Licastro E., Pignataro G., Molinaro P., Annunziato L., Formisano L.
Stroke by inducing HDAC9-dependent deacetylation of HIF-1 and Sp1, promotes TfR1 transcription and GPX4 reduction, thus determining ferroptotic neuronal death
International Journal of Biological Sciences, vol. 19, (no. 9), pp. 2695-2710
2022
Calabrese L., Serani A., Natale S., Tedeschi V., Guida N., Valsecchi V., Secondo A., Formisano L., Annunziato L., Molinaro P.
Identification and characterization of the promoter and transcription factors regulating the expression of cerebral sodium/calcium exchanger 2 (NCX2) gene
Cell Calcium, vol. 102
2021
Guida N., Mascolo L., Serani A., Cuomo O., Anzilotti S., Brancaccio P., Pignataro G., Molinaro P., Annunziato L., Formisano L.
GATA3 (GATA-Binding Protein 3)/KMT2A (Lysine-Methyltransferase-2A) Complex by Increasing H3K4-3me (Trimethylated Lysine-4 of Histone-3) Upregulates NCX3 (Na+-Ca2+Exchanger 3) Transcription and Contributes to Ischemic Preconditioning Neuroprotection
Stroke, vol. 52, (no. 11), pp. 3680-3691
2021
Guida N., Sanguigno L., Mascolo L., Calabrese L., Serani A., Molinaro P., Lau C.G., Annunziato L., Formisano L.
The Transcriptional Complex Sp1/KMT2A by Up-Regulating Restrictive Element 1 Silencing Transcription Factor Accelerates Methylmercury-Induced Cell Death in Motor Neuron-Like NSC34 Cells Overexpressing SOD1-G93A
Frontiers in Neuroscience, vol. 15
2020
Molinaro P., Natale S., Serani A., Calabrese L., Secondo A., Tedeschi V., Valsecchi V., Pannaccione A., Scorziello A., Annunziato L.
Genetically modified mice to unravel physiological and pathophysiological roles played by NCX isoforms
Cell Calcium, vol. 87
2020
Natale S., Anzilotti S., Petrozziello T., Ciccone R., Serani A., Calabrese L., Severino B., Frecentese F., Secondo A., Pannaccione A., Fiorino F., Cuomo O., Vinciguerra A., D'Esposito L., Sadile A.G., Cabib S., Di Renzo G., Annunziato L., Molinaro P.
Genetic Up-Regulation or Pharmacological Activation of the Na+/Ca2+ Exchanger 1 (NCX1) Enhances Hippocampal-Dependent Contextual and Spatial Learning and Memory
Molecular Neurobiology, vol. 57, (no. 5), pp. 2358-2376
2020
Formisano L., Laudati G., Guida N., Mascolo L., Serani A., Cuomo O., Cantile M., Boscia F., Molinaro P., Anzilotti S., Pizzorusso V., Di Renzo G., Pignataro G., Annunziato L.
HDAC4 and HDAC5 form a complex with DREAM that epigenetically down-regulates NCX3 gene and its pharmacological inhibition reduces neuronal stroke damage
Journal of Cerebral Blood Flow and Metabolism, vol. 40, (no. 10), pp. 2081-2097
2020
Valsecchi V., Anzilotti S., Serani A., Laudati G., Brancaccio P., Guida N., Cuomo O., Pignataro G., Annunziato L.
miR-206 Reduces the Severity of Motor Neuron Degeneration in the Facial Nuclei of the Brainstem in a Mouse Model of SMA
Molecular Therapy, vol. 28, (no. 4), pp. 1154-1166
2020
Formisano L., Guida N., Mascolo L., Serani A., Laudati G., Pizzorusso V., Annunziato L.
Transcriptional and epigenetic regulation of ncx1 and ncx3 in the brain
Cell Calcium, vol. 87
2019
Cuomo O., Cepparulo P., Anzilotti S., Serani A., Sirabella R., Brancaccio P., Guida N., Valsecchi V., Vinciguerra A., Molinaro P., Formisano L., Annunziato L., Pignataro G.
Anti-miR-223-5p Ameliorates Ischemic Damage and Improves Neurological Function by Preventing NCKX2 Downregulation after Ischemia in Rats
Molecular Therapy - Nucleic Acids, vol. 18, pp. 1063-1071